The Activity of Human NK Cells Towards 3D Heterotypic Cellular Tumor Model of Breast Cancer

The Activity of Human NK Cells Towards 3D Heterotypic Cellular Tumor Model of Breast Cancer

Due to the complexity of modeling tumor-host interactions within the tumor microenvironment in vitro, we developed a 3D heterotypic cellular breast cancer (BC) model. We generated spheroid models using MCF7, MDA-MB-231, and SK-BR-3 cell lines alongside cancer-associated (BrC4f) and normal (BN120f) f...

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Main Authors: Anastasia Leonteva, Maria Abdurakhmanova, Maria Bogachek, Tatyana Belovezhets, Anna Yurina, Olga Troitskaya, Sergey Kulemzin, Vladimir Richter, Elena Kuligina, Anna Nushtaeva
Format: Article
Language:English
Published: MDPI AG 2025-07-01
Series:Cells
Subjects:
3D cancer cell models
spheroids
co-culture
patient-derived cell culture
tumor microenvironment
stromal cell
Online Access:https://www.mdpi.com/2073-4409/14/14/1039
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https://www.mdpi.com/2073-4409/14/14/1039

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