CAR-T therapy-based innovations in the enhancement of contemporary anti-tumor therapies

CAR-T therapy-based innovations in the enhancement of contemporary anti-tumor therapies

Chimeric antigen receptor T (CAR-T) cell therapy has revolutionized the treatment landscape for hematologic malignancies; however, its efficacy in solid tumors remains limited due to antigen heterogeneity, a suppressive tumor microenvironment, and tumor-intrinsic resistance mechanisms. In parallel,...

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Bibliographic Details
Main Authors: Wan-Ying Zhang, Lang-Yu Yang, Xing-Xing Fan
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Immunology
Subjects:
car-t
tumor microenvironment
artificial intelligence
tumor
immunity
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1622433/full
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