An FGFR3/MYC positive feedback loop provides new opportunities for targeted therapies in bladder cancers

An FGFR3/MYC positive feedback loop provides new opportunities for targeted therapies in bladder cancers

Abstract FGFR3 alterations (mutations or translocation) are among the most frequent genetic events in bladder carcinoma. They lead to an aberrant activation of FGFR3 signaling, conferring an oncogenic dependence, which we studied here. We discovered a positive feedback loop, in which the activation...

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Main Authors: Mélanie Mahe, Florent Dufour, Hélène Neyret‐Kahn, Aura Moreno‐Vega, Claire Beraud, Mingjun Shi, Imene Hamaidi, Virginia Sanchez‐Quiles, Clementine Krucker, Marion Dorland‐Galliot, Elodie Chapeaublanc, Remy Nicolle, Hervé Lang, Celio Pouponnot, Thierry Massfelder, François Radvanyi, Isabelle Bernard‐Pierrot
Format: Article
Language:English
Published: Springer Nature 2018-02-01
Series:EMBO Molecular Medicine
Subjects:
BET inhibitors
bladder cancer
FGFR3
MYC
p38
Online Access:https://doi.org/10.15252/emmm.201708163
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https://doi.org/10.15252/emmm.201708163

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