The CXCR6-CXCL16 axis mediates T cell control of polyomavirus infection in the kidney.

The CXCR6-CXCL16 axis mediates T cell control of polyomavirus infection in the kidney.

BK polyomavirus (PyV) establishes lifelong asymptomatic infections in the reno-urinary system of most humans. BKPyV-associated nephropathy is the leading infectious cause of kidney allograft loss. Using mouse PyV, a natural murine pathogen that also persists in the kidney, we define a dominant chemo...

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Main Authors: Matthew D Lauver, Zoe E Katz, Havell Markus, Nicole M Derosia, Ge Jin, Katelyn N Ayers, Arrienne B Butic, Kaitlyn Bushey, Catherine S Abendroth, Dajiang J Liu, Aron E Lukacher
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2025-03-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1012969
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https://doi.org/10.1371/journal.ppat.1012969

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