Identification of spastic ataxia-related proteins via comparative proteomic analysis of the cerebellum of conditional Ankfy1 knockout mice

Identification of spastic ataxia-related proteins via comparative proteomic analysis of the cerebellum of conditional Ankfy1 knockout mice

Abstract Ankyrin repeat and FYVE domain containing 1 (ANKFY1) is an indispensable protein in the development of cerebellar Purkinje cells. Our preliminary study revealed that its absence caused progressive spastic ataxia, accompanied by the loss of Purkinje cells in mice. Here, we generated Ankfy1-f...

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Bibliographic Details
Main Authors: Rong Fu, Man Ding, Tong Yin, Linlin Zheng, Yue Liu, Hang Yu, Rumeng Zhou, Zuneng Lu
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Ankfy1
Purkinje cell
Spastic ataxia
Data-independent acquisition
Online Access:https://doi.org/10.1038/s41598-025-06398-8
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https://doi.org/10.1038/s41598-025-06398-8

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