Mitochondria-targeting phosphonium salts of monensin A as the source of novel antiproliferative agents

Mitochondria-targeting phosphonium salts of monensin A as the source of novel antiproliferative agents

Monensin A is a representative of natural ionophores, which exhibit a broad spectrum of biological properties, with the most fascinating being its potent anticancer activity. A very intriguing research direction is the rational chemical modification of the monensin A skeleton to obtain analogs with...

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Bibliographic Details
Main Authors: Michał Sulik, Marta Jędrzejczyk, Magdalena Mielczarek-Puta, Gwan Yong Lim, Małgorzata Podsiad, Jakub Hoser, Piotr Bednarczyk, Marta Struga, Adam Huczyński
Format: Article
Language:English
Published: Elsevier 2025-08-01
Series:European Journal of Medicinal Chemistry Reports
Subjects:
Antiproliferative activity
Antibacterial activity
Triphenylphosphonium cation: TPP cation
Mitochondrial membrane potential
Black lipid membrane
Online Access:http://www.sciencedirect.com/science/article/pii/S2772417425000317
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