3D-Q-FISH/Telomere/TRF2 Nanotechnology Identifies a Progressively Disturbed Telomere/Shelterin/Lamin AC Complex as the Common Pathogenic, Molecular/Spatial Denominator of Classical Hodgkin Lymphoma

3D-Q-FISH/Telomere/TRF2 Nanotechnology Identifies a Progressively Disturbed Telomere/Shelterin/Lamin AC Complex as the Common Pathogenic, Molecular/Spatial Denominator of Classical Hodgkin Lymphoma

The bi- or multinucleated Reed–Sternberg cell (RS) is the diagnostic cornerstone of Epstein–Barr Virus (EBV)-positive and EBV-negative classical Hodgkin lymphoma (cHL). cHL is a germinal center (GC)-derived B-cell disease. Hodgkin cells (H) are the mononuclear precursors of RS. An experimental model...

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Bibliographic Details
Main Authors: Hans Knecht, Tina Petrogiannis-Haliotis, Sherif Louis, Sabine Mai
Format: Article
Language:English
Published: MDPI AG 2024-10-01
Series:Cells
Subjects:
Hodgkin lymphoma
Reed–Sternberg cell
nanotechnology
3D Q-FISH
telomere/shelterin
TRF2
Online Access:https://www.mdpi.com/2073-4409/13/21/1748
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