Ex situ heart perfusion: A novel platform to test cardiovascular therapeutics in human hearts

Ex situ heart perfusion: A novel platform to test cardiovascular therapeutics in human hearts

Background: Explanted hearts from recipients undergoing cardiac transplantation may be utilized as a human model of cardiomyopathy. Ex-situ perfusion of hearts allows control of the physiological and biochemical conditions of perfusion. AZD8601 is a novel modRNA for VEGF-A that was shown to be safe...

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Main Authors: John Onsy Louca, Magnus Althage, Marco Öchsner, Aravinda Page, Joao Pedro Nunes, Catherine Wilson, Sanjay Sinha, Simon Messer, James Matt Bae, Mostin Hu, Nicole Asemota, Sarah Fielding, Sai Bhagra, Neil Henderson, Johnny Lindquist, Daniela Später, Anna Collén, Kaushik Sengupta, Benjamin Challis, Justin Perkins, Stephen Large
Format: Article
Language:English
Published: Elsevier 2025-08-01
Series:JHLT Open
Subjects:
Ex-Situ Heart Perfusion
Cardiomyopathy
Drug discovery
Human model of heart failure
Angiogenesis, mRNA therapies, Vascular endothelial growth factor-A
Online Access:http://www.sciencedirect.com/science/article/pii/S2950133425001314
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http://www.sciencedirect.com/science/article/pii/S2950133425001314

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