Risk Factors and Options to Improve Engraftment in Unrelated Cord Blood Transplantation
Use of umbilical unrelated cord-blood (UCB) cells as an alternative source of hematopoietic cell transplantation has been widely used mainly for patients lacking an HLA-matched donor. UCB present many advantages over bone marrow or mobilized peripheral blood from volunteer donors, such as rapid avai...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.4061/2011/610514 |
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| _version_ | 1832567429277941760 |
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| author | Anna D. Petropoulou Vanderson Rocha |
| author_facet | Anna D. Petropoulou Vanderson Rocha |
| author_sort | Anna D. Petropoulou |
| collection | DOAJ |
| description | Use of umbilical unrelated cord-blood (UCB) cells as an alternative source of hematopoietic cell transplantation has been widely used mainly for patients lacking an HLA-matched donor. UCB present many advantages over bone marrow or mobilized peripheral blood from volunteer donors, such as rapid availability, absence of risk for the donor, and decreased incidence of acute graft-versus-host disease. However, a significant clinical problem is delayed engraftment that is directly correlated with the number of hematopoietic stem cells in a cord-blood unit. The identification of prognostic factors associated with engraftment that can be easily modified (e.g., strategies for donor choice) and the development of new approaches including use of multiple donors, intrabone injection of UCB, ex vivo expansion, and cotransplantation with accessory cells are of crucial importance in order to circumvent the problem of delayed engraftment after UCB transplantation. Those approaches may increase the quality and availability of UCB for transplantation. |
| format | Article |
| id | doaj-art-1e9ead3fa5674a5dacdc07df1a8f3905 |
| institution | Kabale University |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-1e9ead3fa5674a5dacdc07df1a8f39052025-02-03T01:01:32ZengWileyStem Cells International1687-966X1687-96782011-01-01201110.4061/2011/610514610514Risk Factors and Options to Improve Engraftment in Unrelated Cord Blood TransplantationAnna D. Petropoulou0Vanderson Rocha1Université de Paris 7, Hospital Saint-Louis, 1, Avenue Claude Vellefaux, 75010 Paris, FranceUniversité de Paris 7, Hospital Saint-Louis, 1, Avenue Claude Vellefaux, 75010 Paris, FranceUse of umbilical unrelated cord-blood (UCB) cells as an alternative source of hematopoietic cell transplantation has been widely used mainly for patients lacking an HLA-matched donor. UCB present many advantages over bone marrow or mobilized peripheral blood from volunteer donors, such as rapid availability, absence of risk for the donor, and decreased incidence of acute graft-versus-host disease. However, a significant clinical problem is delayed engraftment that is directly correlated with the number of hematopoietic stem cells in a cord-blood unit. The identification of prognostic factors associated with engraftment that can be easily modified (e.g., strategies for donor choice) and the development of new approaches including use of multiple donors, intrabone injection of UCB, ex vivo expansion, and cotransplantation with accessory cells are of crucial importance in order to circumvent the problem of delayed engraftment after UCB transplantation. Those approaches may increase the quality and availability of UCB for transplantation.http://dx.doi.org/10.4061/2011/610514 |
| spellingShingle | Anna D. Petropoulou Vanderson Rocha Risk Factors and Options to Improve Engraftment in Unrelated Cord Blood Transplantation Stem Cells International |
| title | Risk Factors and Options to Improve Engraftment in Unrelated Cord Blood Transplantation |
| title_full | Risk Factors and Options to Improve Engraftment in Unrelated Cord Blood Transplantation |
| title_fullStr | Risk Factors and Options to Improve Engraftment in Unrelated Cord Blood Transplantation |
| title_full_unstemmed | Risk Factors and Options to Improve Engraftment in Unrelated Cord Blood Transplantation |
| title_short | Risk Factors and Options to Improve Engraftment in Unrelated Cord Blood Transplantation |
| title_sort | risk factors and options to improve engraftment in unrelated cord blood transplantation |
| url | http://dx.doi.org/10.4061/2011/610514 |
| work_keys_str_mv | AT annadpetropoulou riskfactorsandoptionstoimproveengraftmentinunrelatedcordbloodtransplantation AT vandersonrocha riskfactorsandoptionstoimproveengraftmentinunrelatedcordbloodtransplantation |