In evolution’s unending race: ancestral STING sensors in Salmo salar mediate intracellular bacterial detection and programmed cell death through evolutionarily conserved pathways

In evolution’s unending race: ancestral STING sensors in Salmo salar mediate intracellular bacterial detection and programmed cell death through evolutionarily conserved pathways

Introduction“In evolution’s unending race, survival demands continuous adaptation— to stop is to fall behind.” The Stimulator of Interferon Genes (STING) pathway embodies this principle, acting as a conserved master regulator of cytosolic DNA sensing from Drosophila to salmon and humans. Although ex...

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Main Authors: Alejandro J. Yañez, Jorge F. Beltrán, Claudia A. Barrientos, Genaro Soto-Rauch, Marcelo Aguilar, Adolfo Isla, Sandra N. Flores-Martin, Francisco T. Yañez, Yassef Yuivar, Adriana Ojeda, Felipe Almendras, Patricio Bustos, Marcos Mancilla
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Immunology
Subjects:
STING gene
dynamics activation gene expression
structural functions
innate immune response
Atlantic salmon-pathogen interaction
evolutionary perspectives
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1570871/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2025.1570871/full

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