Golgicide A induces pyroptosis of lung cancer stem cells by regulating dTGN formation via GOLPH3/MYO18A complex

Golgicide A induces pyroptosis of lung cancer stem cells by regulating dTGN formation via GOLPH3/MYO18A complex

Abstract Background Lung cancer is a common malignant neoplasm, one of the leading causes of death worldwide. Cancer stem cells (CSCs) drive tumor recurrence, progression, and therapeutic resistance. Thus, targeting CSCs may contribute to lung cancer treatment and improve clinical outcomes. Methods...

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Main Authors: Feng Zhang, Sun-Han Zhang, Teng Liu, Guang-Su Xie, Shi-Hua Deng, Ting Zhang, Xiao-Bian Wang, Yue-Yan Yang, Zi-Xin Chen, Dong-Ming Wu, Ying Xu
Format: Article
Language:English
Published: BMC 2025-03-01
Series:Stem Cell Research & Therapy
Subjects:
Golgicide A
Pyroptosis
Lung cancer stem cells
trans-Golgi network
GOLPH3/MYO18A
Online Access:https://doi.org/10.1186/s13287-025-04246-0
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https://doi.org/10.1186/s13287-025-04246-0

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