Multiscale, multimodal analysis of tumor heterogeneity in IDH1 mutant vs wild-type diffuse gliomas.

Multiscale, multimodal analysis of tumor heterogeneity in IDH1 mutant vs wild-type diffuse gliomas.

Glioma is recognized to be a highly heterogeneous CNS malignancy, whose diverse cellular composition and cellular interactions have not been well characterized. To gain new clinical- and biological-insights into the genetically-bifurcated IDH1 mutant (mt) vs wildtype (wt) forms of glioma, we integra...

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Main Authors: Michael E Berens, Anup Sood, Jill S Barnholtz-Sloan, John F Graf, Sanghee Cho, Seungchan Kim, Jeffrey Kiefer, Sara A Byron, Rebecca F Halperin, Sara Nasser, Jonathan Adkins, Lori Cuyugan, Karen Devine, Quinn Ostrom, Marta Couce, Leo Wolansky, Elizabeth McDonough, Shannon Schyberg, Sean Dinn, Andrew E Sloan, Michael Prados, Joanna J Phillips, Sarah J Nelson, Winnie S Liang, Yousef Al-Kofahi, Mirabela Rusu, Maria I Zavodszky, Fiona Ginty
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0219724&type=printable
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https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0219724&type=printable

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