Modeling and optimizing deep brain stimulation to enhance gait in Parkinson’s disease: personalized treatment with neurophysiological insights

Modeling and optimizing deep brain stimulation to enhance gait in Parkinson’s disease: personalized treatment with neurophysiological insights

Abstract The effects of deep brain stimulation (DBS) on gait in Parkinson’s disease (PD) are variable due to challenges in gait assessment and limited understanding of stimulation parameters’ impacts on neural activity. We developed a data-driven approach to identify optimal DBS parameters to improv...

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Main Authors: Hamid Fekri Azgomi, Kenneth H. Louie, Jessica E. Bath, Kara N. Presbrey, Jannine P. Balakid, Jacob H. Marks, Thomas A. Wozny, Nicholas B. Galifianakis, Marta San Luciano, Simon Little, Philip A. Starr, Doris D. Wang
Format: Article
Language:English
Published: Nature Portfolio 2025-06-01
Series:npj Parkinson's Disease
Online Access:https://doi.org/10.1038/s41531-025-00990-5
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https://doi.org/10.1038/s41531-025-00990-5

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