Recombinase-mediated reprogramming and dystrophin gene addition in mdx mouse induced pluripotent stem cells.

Recombinase-mediated reprogramming and dystrophin gene addition in mdx mouse induced pluripotent stem cells.

A cell therapy strategy utilizing genetically-corrected induced pluripotent stem cells (iPSC) may be an attractive approach for genetic disorders such as muscular dystrophies. Methods for genetic engineering of iPSC that emphasize precision and minimize random integration would be beneficial. We dem...

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Bibliographic Details
Main Authors: Chunli Zhao, Alfonso P Farruggio, Christopher R R Bjornson, Christopher L Chavez, Jonathan M Geisinger, Tawny L Neal, Marisa Karow, Michele P Calos
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0096279&type=printable
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https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0096279&type=printable

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