Developing a PK-PD model for propofol in exhaled air and the BIS following fospropofol disodium in beagles

Developing a PK-PD model for propofol in exhaled air and the BIS following fospropofol disodium in beagles

Abstract Background Fospropofol, a water-soluble prodrug of propofol, is metabolized into propofol by alkaline phosphatase after administration. This study aimed to develop a pharmacokinetic-pharmacodynamic (PK-PD) model that correlates the propofol concentration in exhaled air (Ce-pro-f) with its a...

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Bibliographic Details
Main Authors: Xiaoxiao Li, Pan Chang, Xing Liu, Yi Kang, Zhongjun Zhao, Yixiang Duan, Wensheng Zhang
Format: Article
Language:English
Published: BMC 2025-02-01
Series:BMC Veterinary Research
Subjects:
Exhaled air
Propofol
Fospropofol
VUV-TOF MS
PK-PD model
Online Access:https://doi.org/10.1186/s12917-025-04570-w
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https://doi.org/10.1186/s12917-025-04570-w

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