TGFβ1 accelerated the progression of diabetic nephropathy via up-regulating BRD4/Notch1/YAP signaling induced fibrosis and proliferation in fibroblasts

TGFβ1 accelerated the progression of diabetic nephropathy via up-regulating BRD4/Notch1/YAP signaling induced fibrosis and proliferation in fibroblasts

Abstract Mounting evidence implicates transforming growth factor-β1 (TGF-β1)-mediated renal tubular cell apoptosis in the pathogenesis of diabetic nephropathy. This investigation sought to elucidate the molecular mechanisms governing the pathogenic role of TGF-β1 in diabetic nephropathy progression....

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Bibliographic Details
Main Authors: Lin Li, Limin Zhang, Zhe Li, Qian Wang, Qian Zhang, Song Li, Juan Ji
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
TGFβ1
BRD4/Notch1/YAP
Diabetic nephropathy
Fibrosis
Online Access:https://doi.org/10.1038/s41598-025-10143-6
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https://doi.org/10.1038/s41598-025-10143-6

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