Staphylococcus Aureus Tames Nociceptive Neurons to Suppress Synovial Macrophage Responses for Sustained Infection in Septic Arthritis

Staphylococcus Aureus Tames Nociceptive Neurons to Suppress Synovial Macrophage Responses for Sustained Infection in Septic Arthritis

Abstract The interaction between the nervous system and immune system during chronic bacterial infection remains unclear. Here, it is reported that Staphylococcus aureus (S. aureus) infection induces calcitonin gene‐related peptide (CGRP) secretion from intra‐articular transient receptor potential c...

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Main Authors: Xinyu Fang, Yang Chen, Haiqi Ding, Changyu Huang, Hongxin Hu, Chaofan Zhang, Yunzhi Lin, Qijin Wang, Xueni Hu, Yiming Lin, Yongfa Chen, Nanxin Zhang, Xuhui Yuan, Ying Huang, Wenbo Li, Susheng Niu, Jianhua Lin, Bin Yang, Tifei Yuan, Wenming Zhang
Format: Article
Language:English
Published: Wiley 2025-04-01
Series:Advanced Science
Subjects:
calcitonin gene‐related peptide
chronic septic arthritis
macrophages
nociceptive neuron
Staphylococcus aureus
Online Access:https://doi.org/10.1002/advs.202409251
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https://doi.org/10.1002/advs.202409251

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