Glioblastoma Cell Migration, Invasion and Vasculogenic Mimicry Downmodulated by Novel uPAcyclin Derivatives

Glioblastoma Cell Migration, Invasion and Vasculogenic Mimicry Downmodulated by Novel uPAcyclin Derivatives

Despite extensive efforts to develop new treatments, the prognosis for glioblastoma multiforme (GBM) is extremely unfavorable, urging the identification of new chemotherapeutics. A previous work identified the cyclic decapeptide uPAcyclin as a potent inhibitor of GBM cell migration, matrix invasion...

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Main Authors: Federica Santoro, Francesco Merlino, Diego Brancaccio, Iolanda Camerino, Stefania Belli, Amelia Cimmino, Paolo Grieco, Luca Colucci-D’Amato, Maria Patrizia Stoppelli, Paola Franco, Alfonso Carotenuto
Format: Article
Language:English
Published: MDPI AG 2025-02-01
Series:Cells
Subjects:
glioblastoma
cyclic peptides
vasculogenic mimicry
tumor migration
tumor invasion
Online Access:https://www.mdpi.com/2073-4409/14/4/259
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