Aristolochic acid I orchestrates multi-organ carcinogenesis through apoptotic pathway in bladder, kidney, and liver cancers: a multi-omics dissection

Aristolochic acid I orchestrates multi-organ carcinogenesis through apoptotic pathway in bladder, kidney, and liver cancers: a multi-omics dissection

Abstract Aristolochic acid I (AA-I), a naturally occurring compound derived from plants of the genus Aristolochia, is a well-documented nephrotoxin and carcinogen linked to bladder (BLCA), kidney (KIRC), and liver (LIHC) cancers. Despite extensive research, the molecular mechanisms underlying AA-I-i...

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Bibliographic Details
Main Authors: Bitian Zhang, Ping-Chung Leung, Chun-Kwok Wong, Dongjie Wang
Format: Article
Language:English
Published: SpringerOpen 2025-06-01
Series:Environmental Sciences Europe
Subjects:
Aristolochic acid I
Apoptosis dysregulation
Computational analysis
In silico multi-omics analysis
Tumor microenvironment
Online Access:https://doi.org/10.1186/s12302-025-01146-1
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https://doi.org/10.1186/s12302-025-01146-1

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