BRISC inactivation alleviates alcohol-induced liver injury in mice

BRISC inactivation alleviates alcohol-induced liver injury in mice

Abstract BRCC3 isopeptidase complex (BRISC) is a JAMM subfamily deubiquitinase that has been revealed to be required for optional activation of NLRP3 inflammasome and TLR4/NF-κB signaling pathway. BRISC plays an important role in lipopolysaccharide (LPS)/D-galactosamine-induced acute liver failure,...

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Main Authors: Ting Wang, Wen Zhang, Xian Liu, Kai Liu, Guang-Ming Ren, Shen-Si Xiang, Yi-Qun Zhan, Hui Chen, Hui-Ying Gao, Ke Zhao, Miao Yu, Chang-Yan Li, Xiao-Ming Yang, Rong-Hua Yin
Format: Article
Language:English
Published: Nature Portfolio 2025-02-01
Series:Scientific Reports
Subjects:
Alcoholic liver disease
BRISC
Thiolutin
Liver steatosis
Inflammation
NLRP3 inflammasome
Online Access:https://doi.org/10.1038/s41598-025-89796-2
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https://doi.org/10.1038/s41598-025-89796-2

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