High-throughput sequencing unravels placental vascular dysfunction and oxidative stress as mechanistic drivers of advanced maternal age-associated pregnancy

High-throughput sequencing unravels placental vascular dysfunction and oxidative stress as mechanistic drivers of advanced maternal age-associated pregnancy

IntroductionWomen with advanced maternal age (AMA) face a higher risk of pregnancy complications including preeclampsia, fetal growth restriction, and preterm birth. While placental dysfunction is implicated, the underlying mechanisms remain unclear. This study employs high-throughput sequencing-bas...

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Bibliographic Details
Main Authors: Xin Sun, Yao Chen, Feifei Hu, Yumeng Qiao, He Wu, Yao Su, Yue Hu, Jie Wu, Mingli Huang
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Genetics
Subjects:
placental transcriptome sequencing
placental vascular injury
oxidative stress
advanced maternal age
SIRT3
Online Access:https://www.frontiersin.org/articles/10.3389/fgene.2025.1636834/full
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https://www.frontiersin.org/articles/10.3389/fgene.2025.1636834/full

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