Restoring Tumor Cell Immunogenicity Through Ion‐Assisted p53 mRNA Domestication for Enhanced In Situ Cancer Vaccination Effect

Restoring Tumor Cell Immunogenicity Through Ion‐Assisted p53 mRNA Domestication for Enhanced In Situ Cancer Vaccination Effect

Abstract The efficacy of in situ cancer vaccines (ISCVs) is hindered by the poor immunogenicity of tumor cells. Here, PRIZE, a P53‐repair nanosystem based on a virus‐mimicking nanostructure to deliver p53 mRNA and Zn (II) into tumor cells, domesticating tumor cells by restoring intracellular P53 lev...

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Bibliographic Details
Main Authors: Yan Liang, Jingge Zhang, Jinjin Wang, Yuhe Yang, Xinyu Tan, Shuguang Li, Zhenzhen Guo, Zhenzhong Zhang, Junjie Liu, Jinjin Shi, Kaixiang Zhang
Format: Article
Language:English
Published: Wiley 2025-04-01
Series:Advanced Science
Subjects:
cancer immune
in situ cancer vaccine
mRNA delivery
p53
tumor cell immunogenicity
Online Access:https://doi.org/10.1002/advs.202500825
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https://doi.org/10.1002/advs.202500825

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