Adeno-associated virus-clustered regularly interspaced short palindromic repeats/cas9‑mediated ovarian cancer treatment targeting PD-L1

Adeno-associated virus-clustered regularly interspaced short palindromic repeats/cas9‑mediated ovarian cancer treatment targeting PD-L1

Abstract The response rate of antibody therapy targeting immune checkpoint molecules in ovarian cancer is insufficient. This study aimed to develop a novel gene immunotherapy model targeting programmed death ligand 1 (PD-L1) in vivo in ovarian cancer using adeno-associated virus (AAV)-clustered regu...

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Main Authors: Tamaki Yahata, Saori Toujima, Izumi Sasaki, Naoyuki Iwahashi, Megumi Fujino, Kaho Nishioka, Tomoko Noguchi, Yuko Tanizaki-Horiuchi, Tsuneyasu Kaisho, Kazuhiko Ino
Format: Article
Language:English
Published: BMC 2025-04-01
Series:BMC Cancer
Subjects:
PD-L1
AAV-CRISPR/Cas9
Ovarian cancer
Genome editing
Online Access:https://doi.org/10.1186/s12885-025-14093-0
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https://doi.org/10.1186/s12885-025-14093-0

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