A LINC00472-encoded polypeptide impedes migration and proliferation through modulation of the HDAC2/SP1 axis in non-small cell lung cancer cells

A LINC00472-encoded polypeptide impedes migration and proliferation through modulation of the HDAC2/SP1 axis in non-small cell lung cancer cells

Abstract Objective While long non-coding RNAs (lncRNAs) are increasingly recognized as sources of functional micropeptides, their roles in non-small cell lung cancer (NSCLC) remain poorly characterized. This study investigates the therapeutic potential and molecular mechanism of LINC00472-encoded po...

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Bibliographic Details
Main Authors: Lei Xu, Haoyong Kuang, Haodong Peng, Sen Wu, Yu Bai, Xiangbo Jia, Wenjian Yao
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Cancer Cell International
Subjects:
lncRNA-encoded polypeptide
LINC00472
HDAC2/SP1 axis
Multi-omics screening
NSCLC
Epigenetic-transcriptional regulation
Online Access:https://doi.org/10.1186/s12935-025-03901-z
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https://doi.org/10.1186/s12935-025-03901-z

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