Macrophage Plasticity and the Role of Inflammation in Skeletal Muscle Repair
Effective repair of damaged tissues and organs requires the coordinated action of several cell types, including infiltrating inflammatory cells and resident cells. Recent findings have uncovered a central role for macrophages in the repair of skeletal muscle after acute damage. If damage persists, a...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2013/491497 |
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| author | Yacine Kharraz Joana Guerra Christopher J. Mann Antonio L. Serrano Pura Muñoz-Cánoves |
| author_facet | Yacine Kharraz Joana Guerra Christopher J. Mann Antonio L. Serrano Pura Muñoz-Cánoves |
| author_sort | Yacine Kharraz |
| collection | DOAJ |
| description | Effective repair of damaged tissues and organs requires the coordinated action of several cell types, including infiltrating inflammatory cells and resident cells. Recent findings have uncovered a central role for macrophages in the repair of skeletal muscle after acute damage. If damage persists, as in skeletal muscle pathologies such as Duchenne muscular dystrophy (DMD), macrophage infiltration perpetuates and leads to progressive fibrosis, thus exacerbating disease severity. Here we discuss how dynamic changes in macrophage populations and activation states in the damaged muscle tissue contribute to its efficient regeneration. We describe how ordered changes in macrophage polarization, from M1 to M2 subtypes, can differently affect muscle stem cell (satellite cell) functions. Finally, we also highlight some of the new mechanisms underlying macrophage plasticity and briefly discuss the emerging implications of lymphocytes and other inflammatory cell types in normal versus pathological muscle repair. |
| format | Article |
| id | doaj-art-1df5bd2679c94fa7b9a2a50a6a63b3dc |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-1df5bd2679c94fa7b9a2a50a6a63b3dc2025-02-03T01:24:20ZengWileyMediators of Inflammation0962-93511466-18612013-01-01201310.1155/2013/491497491497Macrophage Plasticity and the Role of Inflammation in Skeletal Muscle RepairYacine Kharraz0Joana Guerra1Christopher J. Mann2Antonio L. Serrano3Pura Muñoz-Cánoves4Cell Biology Group, Department of Experimental and Health Sciences, Pompeu Fabra University (UPF) and CIBER on Neurodegenerative Diseases (CIBERNED), 08003 Barcelona, SpainCell Biology Group, Department of Experimental and Health Sciences, Pompeu Fabra University (UPF) and CIBER on Neurodegenerative Diseases (CIBERNED), 08003 Barcelona, SpainCell Biology Group, Department of Experimental and Health Sciences, Pompeu Fabra University (UPF) and CIBER on Neurodegenerative Diseases (CIBERNED), 08003 Barcelona, SpainCell Biology Group, Department of Experimental and Health Sciences, Pompeu Fabra University (UPF) and CIBER on Neurodegenerative Diseases (CIBERNED), 08003 Barcelona, SpainCell Biology Group, Department of Experimental and Health Sciences, Pompeu Fabra University (UPF) and CIBER on Neurodegenerative Diseases (CIBERNED), 08003 Barcelona, SpainEffective repair of damaged tissues and organs requires the coordinated action of several cell types, including infiltrating inflammatory cells and resident cells. Recent findings have uncovered a central role for macrophages in the repair of skeletal muscle after acute damage. If damage persists, as in skeletal muscle pathologies such as Duchenne muscular dystrophy (DMD), macrophage infiltration perpetuates and leads to progressive fibrosis, thus exacerbating disease severity. Here we discuss how dynamic changes in macrophage populations and activation states in the damaged muscle tissue contribute to its efficient regeneration. We describe how ordered changes in macrophage polarization, from M1 to M2 subtypes, can differently affect muscle stem cell (satellite cell) functions. Finally, we also highlight some of the new mechanisms underlying macrophage plasticity and briefly discuss the emerging implications of lymphocytes and other inflammatory cell types in normal versus pathological muscle repair.http://dx.doi.org/10.1155/2013/491497 |
| spellingShingle | Yacine Kharraz Joana Guerra Christopher J. Mann Antonio L. Serrano Pura Muñoz-Cánoves Macrophage Plasticity and the Role of Inflammation in Skeletal Muscle Repair Mediators of Inflammation |
| title | Macrophage Plasticity and the Role of Inflammation in Skeletal Muscle Repair |
| title_full | Macrophage Plasticity and the Role of Inflammation in Skeletal Muscle Repair |
| title_fullStr | Macrophage Plasticity and the Role of Inflammation in Skeletal Muscle Repair |
| title_full_unstemmed | Macrophage Plasticity and the Role of Inflammation in Skeletal Muscle Repair |
| title_short | Macrophage Plasticity and the Role of Inflammation in Skeletal Muscle Repair |
| title_sort | macrophage plasticity and the role of inflammation in skeletal muscle repair |
| url | http://dx.doi.org/10.1155/2013/491497 |
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