HIF1α-PHD1-FOXA1 Axis Orchestrates Hypoxic Reprogramming and Androgen Signaling Suppression in Prostate Cancer

HIF1α-PHD1-FOXA1 Axis Orchestrates Hypoxic Reprogramming and Androgen Signaling Suppression in Prostate Cancer

Hypoxia is a hallmark of aggressive prostate cancer, but how it disrupts lineage-specific transcriptional programs to drive progression remains unclear. Here, we identify the HIF1α-PHD1-FOXA1 axis as a critical mediator of hypoxic adaptation and androgen signaling suppression. Using genome-wide prof...

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Bibliographic Details
Main Authors: Limiao Liang, Dandan Dong, Jiaxue Sun, Qin Zhang, Xiayun Yang, Gong-Hong Wei, Peng Zhang
Format: Article
Language:English
Published: MDPI AG 2025-07-01
Series:Cells
Subjects:
HIF1α
cistrome reprogramming
PHD1
FOXA1
prostate cancer
Online Access:https://www.mdpi.com/2073-4409/14/13/1008
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