The efficacy and safety of FOLFOX therapy for advanced esophageal squamous cell carcinoma

Abstract Cisplatin-based chemotherapy is the standard advanced esophageal squamous cell carcinoma (ESCC) treatment. However, the 5-fluorouracil plus L-leucovorin and oxaliplatin (FOLFOX) regimen is available in Japan as an alternative to cisplatin-based chemotherapy, but its efficacy and safety rema...

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Main Authors: Kazuhiro Shiraishi, Mao Okada, Shun Yamamoto, Yuki Matsubara, Toshiki Masuishi, Keitaro Shimozaki, Yoshiyuki Yamamoto, Suguru Hirose, Keiji Sugiyama, Mitsuhiro Furuta, Nozomu Machida, Naoki Takahashi, Takako Yoshii, Yosuke Kito, Takao Tsuzuki, Shogen Boku, Kenji Tsuchihashi, Akinori Sugaya, Toshizo Takayama, Azusa Komori, Seiichiro Mitani, Toshihiko Matsumoto, Takashi Nishimura, Kenro Hirata
Format: Article
Language:English
Published: Nature Portfolio 2025-03-01
Series:Scientific Reports
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Online Access:https://doi.org/10.1038/s41598-025-92657-7
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