Deciphering the interplay between SETD2 mediated H3K36me3 and RNA N6-methyladenosine in clear cell renal cell carcinoma (ccRCC)

Deciphering the interplay between SETD2 mediated H3K36me3 and RNA N6-methyladenosine in clear cell renal cell carcinoma (ccRCC)

RNA N6-methyladenosine (m6A) plays diverse roles in RNA metabolism and its deregulation contributes to tumor initiation and progression. Clear cell renal cell carcinoma (ccRCC) is characterized by near ubiquitous loss of VHL followed by mutations in epigenetic regulators PBRM1, SETD2, and BAP1. Muta...

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Bibliographic Details
Main Authors: Shafiq Shaikh, Xia Zhao, Ryan T. Wagner, Xiaoyu Pan, Ryan A. Hlady, Liguo Wang, Thai H. Ho, Keith D. Robertson
Format: Article
Language:English
Published: Taylor & Francis Group 2025-12-01
Series:Epigenetics
Subjects:
H3K36me3
SETD2
N6-methyladenosine (m6A)
METTL3
STM2457
H3K27ac
Online Access:https://www.tandfonline.com/doi/10.1080/15592294.2025.2456418
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https://www.tandfonline.com/doi/10.1080/15592294.2025.2456418

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