Facilitate integrated analysis of single cell multiomic data by binarizing gene expression values

Abstract A cell type’s identity can be revealed by its transcriptome and epigenome profiles, both of which can be in flux temporally and spatially, leading to distinct cell states or subtypes. The popular and standard workflow for single cell RNA-seq (scRNA-seq) data analysis applies feature selecti...

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Bibliographic Details
Main Authors: Rohan Misra, Alexander Ferrena, Deyou Zheng
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-60899-8
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