A multicenter study on TROP2 as a potential targeted therapy for extramammary Paget disease in Japan

A multicenter study on TROP2 as a potential targeted therapy for extramammary Paget disease in Japan

Abstract Extramammary Paget disease (EMPD) is a rare skin cancer that typically occurs in the anogenital area of older people. Since efficacy of treatments for metastatic or unresectable EMPD remains poor, development of a novel therapeutic approach is strongly desired. However, the lack of EMPD mod...

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Main Authors: Takamichi Ito, Yuka Tanaka, Dai Ogata, Haruto Nishida, Tatsushi Shiomi, Ryo Tanaka, Aya Kawaguchi, Azusa Miyashita, Satoshi Fukushima, Naoko Shojiguchi, Hiroyuki Goto, Yaei Togawa, Takahiro Kiyohara, Yoshinao Oda, Takeshi Nakahara
Format: Article
Language:English
Published: Nature Portfolio 2025-01-01
Series:Scientific Reports
Subjects:
Extramammary Paget disease
Trophoblast cell surface antigen 2
Antibody–drug conjugate
Sacituzumab govitecan
Online Access:https://doi.org/10.1038/s41598-024-84566-y
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https://doi.org/10.1038/s41598-024-84566-y

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