PLB2Tau mice are impaired in novel and temporal object recognition and show corresponding traits in brain MRI

PLB2Tau mice are impaired in novel and temporal object recognition and show corresponding traits in brain MRI

Recent clinical trials targeting tau protein aggregation have heightened interest in tau-based therapies for dementia. Success of such treatments depends crucially on translation from non-clinical animal models. Here, we present the age profile of the PLB2Tau knock-in model of fronto-temporal dement...

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Bibliographic Details
Main Authors: Jacques Micheau, Gwenaelle Catheline, Elodie Barse, Bassem Hiba, Anne Marcilhac, Michèle Allard, Bettina Platt, Gernot Riedel
Format: Article
Language:English
Published: Elsevier 2025-01-01
Series:Brain Research Bulletin
Subjects:
HTau KI mice
Age profile
Object recognition
Episodic-like memory
MRI
ROIs volume
Online Access:http://www.sciencedirect.com/science/article/pii/S0361923024002958
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http://www.sciencedirect.com/science/article/pii/S0361923024002958

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