Low dose Adenoviral Vammin gene transfer induces myocardial angiogenesis and increases left ventricular ejection fraction in ischemic porcine heart

Low dose Adenoviral Vammin gene transfer induces myocardial angiogenesis and increases left ventricular ejection fraction in ischemic porcine heart

Abstract This preliminary study investigated if VEGFR-2 selective adenoviral Vammin (AdVammin) gene therapy could induce angiogenesis and increase perfusion in the healthy porcine myocardium. Also, we determined using a clinically relevant large animal model if AdVammin gene therapy could improve th...

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Main Authors: Niko Järveläinen, Paavo J. Halonen, Jussi Nurro, Antti Kuivanen, Juho Pajula, Miikka Tarkia, Maria Grönman, Antti Saraste, Johanna Laakkonen, Pyry Toivanen, Tiina Nieminen, Tuomas T. Rissanen, Juhani Knuuti, Seppo Ylä-Herttuala
Format: Article
Language:English
Published: Nature Portfolio 2024-12-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-024-81773-5
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https://doi.org/10.1038/s41598-024-81773-5

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