One-year mortality of tuberculosis patients on isoniazid-based treatment and its association with rapid acetylator NAT2 genotypes

One-year mortality of tuberculosis patients on isoniazid-based treatment and its association with rapid acetylator NAT2 genotypes

Background: NAT2 polymorphisms affect isoniazid metabolism, but their effect on mortality among individuals with tuberculosis (TB) remains unclear. Methods: This study used data from two TB cohorts (2005–2011, 2014–2020) and death certificate records in Thailand. Newly diagnosed Thai individuals tre...

Full description

Saved in:
Bibliographic Details
Main Authors: Ayu Kasamatsu, Reiko Miyahara, Daisuke Yoneoka, Licht Toyo-oka, Boonchai Chiyasirinroje, Worarat Imsanguan, Supharat Suvichapanich, Hideki Yanai, Sukanya Wattnapokayakit, Supalert Nedsuwan, Manon Boonbangyang, Prasit Palittapongarnpim, Katsushi Tokunaga, Taisei Mushiroda, Surakameth Mahasirimongkol
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:International Journal of Infectious Diseases
Subjects:
Tuberculosis
Survival
Pharmacokinetics
Isoniazid
NAT2 genotype
Drug resistance
Online Access:http://www.sciencedirect.com/science/article/pii/S1201971225001183
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

http://www.sciencedirect.com/science/article/pii/S1201971225001183

Similar Items