Human neural stem cells directly programmed from peripheral blood show functional integration into the adult mouse brain

Human neural stem cells directly programmed from peripheral blood show functional integration into the adult mouse brain

Abstract Transplantation of induced pluripotent stem cell-derived neural cells represents a promising strategy for treating neurodegenerative diseases. However, reprogramming of somatic cells and their subsequent neural differentiation is complex and time-consuming, thereby impeding autologous appli...

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Main Authors: Lea Jessica Berg, Chung Ku Lee, Hideaki Matsumura, Anke Leinhaas, Rachel Konang, Ali H. Shaib, Pedro Royero, Julia Schlee, Chao Sheng, Heinz Beck, Martin Karl Schwarz, Nils Brose, Jeong Seop Rhee, Oliver Brüstle
Format: Article
Language:English
Published: BMC 2024-12-01
Series:Stem Cell Research & Therapy
Subjects:
Cell programming
Direct conversion
Induced neural stem cells
Transplantation
Neural network integration
Online Access:https://doi.org/10.1186/s13287-024-04110-7
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https://doi.org/10.1186/s13287-024-04110-7

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