Arginase II Contributes to the Ca2+/CaMKII/eNOS Axis by Regulating Ca2+ Concentration Between the Cytosol and Mitochondria in a p32‐Dependent Manner

Arginase II Contributes to the Ca2+/CaMKII/eNOS Axis by Regulating Ca2+ Concentration Between the Cytosol and Mitochondria in a p32‐Dependent Manner

Background Arginase II activity contributes to reciprocal regulation of endothelial nitric oxide synthase (eNOS). We tested the hypotheses that arginase II activity participates in the regulation of Ca2+/Ca2+/calmodulin‐dependent kinase II/eNOS activation, and this process is dependent on mitochondr...

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Main Authors: Bon‐Hyeock Koo, Hye‐Mi Hwang, Bong‐Gu Yi, Hyun Kyo Lim, Byeong Hwa Jeon, Kwang Lae Hoe, Young‐Guen Kwon, Moo‐Ho Won, Young Myeong Kim, Dan E. Berkowitz, Sungwoo Ryoo
Format: Article
Language:English
Published: Wiley 2018-09-01
Series:Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Subjects:
Arginase II
atherogenesis
Calcium signaling
eNOS
p32
Online Access:https://www.ahajournals.org/doi/10.1161/JAHA.118.009579
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https://www.ahajournals.org/doi/10.1161/JAHA.118.009579

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