Priming of mouse pre-osteoblasts with Interleukin-3 attenuates TNF-α-induced-inhibition of osteoblast differentiation

Priming of mouse pre-osteoblasts with Interleukin-3 attenuates TNF-α-induced-inhibition of osteoblast differentiation

Abstract Background In inflammatory bone loss disorders, such as rheumatoid arthritis and post-menopausal osteoporosis, TNF-α is an important effector cytokine that promotes osteoclastogenesis and inhibits osteoblastogenesis. Currently, clinical interventions primarily include anti-osteoclastic agen...

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Bibliographic Details
Main Authors: Vikrant Piprode, Shubhanath Behera, Juilee Karhade, Suhas T. Mhaske, Mohan R. Wani
Format: Article
Language:English
Published: BMC 2025-07-01
Series:BMC Musculoskeletal Disorders
Subjects:
IL- 3
TNF-α
Osteoblastogenesis
Alkaline phosphatase
Osteocalcin
NF-κB/β-CATENIN
Online Access:https://doi.org/10.1186/s12891-025-08610-2
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https://doi.org/10.1186/s12891-025-08610-2

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