The Remarkable and Selective In Vitro Cytotoxicity of Synthesized Bola-Amphiphilic Nanovesicles on Etoposide-Sensitive and -Resistant Neuroblastoma Cells

The Remarkable and Selective In Vitro Cytotoxicity of Synthesized Bola-Amphiphilic Nanovesicles on Etoposide-Sensitive and -Resistant Neuroblastoma Cells

Neuroblastoma (NB) is a solid tumor occurring in infancy and childhood. Its high-risk form has currently a survival rate <50%, despite aggressive treatments. This worrying scenario is worsened by drug-induced secondary tumorigenesis and the emergency of drug resistance, calling for the urgent dev...

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Bibliographic Details
Main Authors: Silvana Alfei, Paolo Giannoni, Maria Grazia Signorello, Carola Torazza, Guendalina Zuccari, Constantinos M. Athanassopoulos, Cinzia Domenicotti, Barbara Marengo
Format: Article
Language:English
Published: MDPI AG 2024-09-01
Series:Nanomaterials
Subjects:
high-risk neuroblastoma (HR-NB)
HTLA-230 NB and HTLA-ER cells
triphenyl phosphonium groups
mitochondrial targets
bola-amphiphiles
nanosized vesicles
Online Access:https://www.mdpi.com/2079-4991/14/18/1505
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