LINE1 insertion into the NACC2 locus disrupts the HDM2 axis and activates lung oncogenic signaling
Abstract Although long interspersed element-1 (LINE-1) retrotransposons are poor prognostic indicators of non-small cell lung cancer, the genetic consequences of aberrant LINE-1 expression remain poorly understood. In this study, human bronchial epithelial cells were exposed chronically to 25 µM NiC...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2025-07-01
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| Series: | npj Precision Oncology |
| Online Access: | https://doi.org/10.1038/s41698-025-01050-0 |
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