Efficacy and mechanism of action of cipargamin as an antibabesial drug candidate

Efficacy and mechanism of action of cipargamin as an antibabesial drug candidate

Babesiosis is a disease brought on by intraerythrocytic parasites of the genus Babesia. Current chemotherapies are accompanied by side effects and parasite relapse. Therefore, it is crucial to develop highly effective drugs against Babesia. Cipargamin (CIP) has shown inhibition against apicomplexan...

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Main Authors: Hang Li, Shengwei Ji, Nanang R Ariefta, Eloiza May S Galon, Shimaa AES El-Sayed, Thom Do, Lijun Jia, Miako Sakaguchi, Masahito Asada, Yoshifumi Nishikawa, Xin Qin, Mingming Liu, Xuenan Xuan
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2025-06-01
Series:eLife
Subjects:
Babesia spp.
cipargamin
drug resistance
Online Access:https://elifesciences.org/articles/101128
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https://elifesciences.org/articles/101128

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