Maternal diet-induced alterations in uterine fluid sncRNAs compromise preimplantation embryo development and offspring metabolic health

Maternal diet-induced alterations in uterine fluid sncRNAs compromise preimplantation embryo development and offspring metabolic health

Abstract The periconception period is critical for embryo development, pregnancy outcomes, and offspring health. During this stage, oviductal and uterine fluids facilitate embryo-maternal interactions and support early embryonic development. Using PANDORA-seq, we identify a diverse repertoire of sma...

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Main Authors: Shijia Pan, Liwen Zhang, Xinai Yang, Lumen Wang, Changze Liu, Jia Zhang, Xuemei Yu, Simin Qiao, Ruoyang Zeng, Yu Qian, Li Tong, Xinxin Liu, Junchao Shi, Lei Yan, Ying Zhang
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-63054-5
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https://doi.org/10.1038/s41467-025-63054-5

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