Single-cell RNA sequencing analysis revealed the immunosuppressive remodeling of tumor-associated macrophages mediated by the MIF-CD74 axis in gastric cancer

Single-cell RNA sequencing analysis revealed the immunosuppressive remodeling of tumor-associated macrophages mediated by the MIF-CD74 axis in gastric cancer

Abstract Tumor-associated macrophages (TAMs) are pivotal immunosuppressive components of the tumor microenvironment (TME) in gastric cancer (GC), yet their heterogeneity and metabolic crosstalk with tumor cells remain poorly understood. Here, we performed single-cell RNA sequencing (scRNA-seq) on 75...

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Bibliographic Details
Main Authors: Weiwei Liu, Chuangyuan Wang, Lixin Liang, Congcong Zhang, Yanyan Li, Jun Xiao, Rui Zeng, Jingyu Li, Zhihao Lin, Qinghua Huang, Lisheng Zheng, Qingling Zhang
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Gastric cancer
Tumor-associated macrophages
Single-cell RNA sequencing
MIF-CD74 axis
Immunotherapy
Online Access:https://doi.org/10.1038/s41598-025-10301-w
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https://doi.org/10.1038/s41598-025-10301-w

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