Baricitinib represses the myocardial fibrosis via blocking JAK/STAT and TGF-β1 pathways in vivo and in vitro

Baricitinib represses the myocardial fibrosis via blocking JAK/STAT and TGF-β1 pathways in vivo and in vitro

Abstract Background JAK/STAT pathway is closely involved in the organ fibrotic process. The current study aimed to investigate the impact of baricitinib, an oral selective JAK1/JAK2 inhibitor, on the myocardial fibrosis in vivo and the activation of cardiac fibroblasts in vitro. Methods The mouse my...

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Bibliographic Details
Main Authors: Renlei Feng, Hongli Liu, Yunqing Chen
Format: Article
Language:English
Published: BMC 2025-01-01
Series:BMC Cardiovascular Disorders
Subjects:
Baricitinib
JAK/STAT
Myocardial fibrosis
Cardiac fibroblasts
JAK2 knockdown
Online Access:https://doi.org/10.1186/s12872-025-04517-x
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https://doi.org/10.1186/s12872-025-04517-x

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