Therapeutic effects of PDGF-AB/BB against cellular senescence in human intervertebral disc

Therapeutic effects of PDGF-AB/BB against cellular senescence in human intervertebral disc

Accumulation of senescent cells is closely linked with intervertebral disc (IVD) degeneration, a prevalent age-dependent chronic disorder causing low back pain. While previous studies have highlighted that platelet-derived growth factor (PDGF) mitigated IVD degeneration through anti-apoptotic and pr...

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Bibliographic Details
Main Authors: Changli Zhang, Martha Elena Diaz-Hernandez, Takanori Fukunaga, Sreekala Shenoy, Sangwook Tim Yoon, Lisbet Haglund, Hicham Drissi
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2025-07-01
Series:eLife
Subjects:
cellular senescence
PDGF
intervertebral disc degeneration
irradiation
oxidative stress
reactive oxygen species
Online Access:https://elifesciences.org/articles/103073
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https://elifesciences.org/articles/103073

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