How allosteric mutations control ligand binding in Lipocalin protein: odorant binding protein as a test case

How allosteric mutations control ligand binding in Lipocalin protein: odorant binding protein as a test case

Abstract Lipocalins are a family of proteins found in mammals that are essential for the binding and transport of various molecules, but the mechanisms underlying their target recognition are still unclear. To answer this question, we studied odorant-binding proteins (OBPs), a specific type of lipoc...

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Bibliographic Details
Main Authors: Maxence Lalis, Lucie Moitrier, Miriam Jäger, Cornelia Meinert, Marine Brulé, Christine Belloir, Nykola C. Jones, Søren V. Hoffmann, Sébastien Fiorucci, Steffen Wolf, Loïc Briand, Jérémie Topin
Format: Article
Language:English
Published: Springer 2025-06-01
Series:Cellular and Molecular Life Sciences
Subjects:
Molecular dynamics
Site-directed mutagenesis
Circular dichroism
Isothermal titration calorimetry
Lipocalin
Odorant binding protein
Online Access:https://doi.org/10.1007/s00018-025-05777-8
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https://doi.org/10.1007/s00018-025-05777-8

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