Conserved and unique features of terminal telomeric sequences in ALT-positive cancer cells

A significant portion of human cancers utilize a recombination-based pathway, alternative lengthening of telomeres (ALT), to maintain telomere length. Targeting the ALT is of growing interest as a cancer therapy, yet a substantial knowledge gap remains regarding the basic features of telomeres in AL...

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Bibliographic Details
Main Authors: Benura Azeroglu, Wei Wu, Raphael Pavani, Ranjodh Singh Sandhu, Tadahiko Matsumoto, André Nussenzweig, Eros Lazzerini-Denchi
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2025-08-01
Series:eLife
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Online Access:https://elifesciences.org/articles/106657
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