The role of HDAC2 inhibition in cardioprotection against doxorubicin-induced myocardial injury

The role of HDAC2 inhibition in cardioprotection against doxorubicin-induced myocardial injury

IntroductionThe molecular mechanisms underlying cardioprotection against doxorubicin (DOX)-induced myocardial injury are poorly understood. Histone deacetylase 2 (HDAC2) plays a significant role in oxidative stress, apoptosis, and mitochondrial dysfunction and is implicated in many human diseases, T...

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Bibliographic Details
Main Authors:	Jinsha Liu, Wenwen Fu, Xue Wang, Zuowen Liang, Fanbo Meng
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-02-01
Series:	Frontiers in Cardiovascular Medicine
Subjects:	HDAC2 doxorubicin cardiac function PI3K/AKT apoptosis
Online Access:	https://www.frontiersin.org/articles/10.3389/fcvm.2025.1557119/full
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