The Biflavonoid Agathisflavone Regulates Microglial and Astrocytic Inflammatory Profiles via Glucocorticoid Receptor

The Biflavonoid Agathisflavone Regulates Microglial and Astrocytic Inflammatory Profiles via Glucocorticoid Receptor

Nuclear receptors such as glucocorticoid receptors (GRs) are transcription factors with prominent regulatory effects on neuroinflammation. Agathisflavone is a biflavonoid that demonstrates neurogenic, neuroprotective, anti-inflammatory, antioxidant, and pro-myelinogenic effects in vitro. This study...

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Main Authors: Áurea Maria Alves Nunes Almeida, Cleonice Creusa dos Santos, Daniele Takahashi, Larissa Pereira da Silva, Verônica Moreira de Sousa, Monique Reis de Santana, Ana Elisa Del Arco, Balbino Lino dos Santos, Jorge Mauricio David, Victor Diogenes Amaral da Silva, Suzana Braga-de-Souza, Silvia Lima Costa
Format: Article
Language:English
Published: MDPI AG 2025-02-01
Series:Molecules
Subjects:
anti-neuroinflammatory
IL-10
astrocyte
microglia
neuroprotection
flavonoid
Online Access:https://www.mdpi.com/1420-3049/30/5/1014
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