Reducing Haemorrhagic Transformation after Thrombolysis for Stroke: A Strategy Utilising Minocycline

Haemorrhagic transformation (HT) of recently ischaemic brain is a feared complication of thrombolytic therapy that may be caused or compounded by ischaemia-induced activation of matrix metalloproteinases (MMPs). The tetracycline antibiotic minocycline inhibits matrix MMPs and reduces macroscopic HT...

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Bibliographic Details
Main Authors: David J. Blacker, David Prentice, Anthony Alvaro, Timothy R. Bates, Michael Bynevelt, Andrew Kelly, Lay Kun Kho, Edith Kohler, Graeme J. Hankey, Andrew Thompson, Taryn Major
Format: Article
Language:English
Published: Wiley 2013-01-01
Series:Stroke Research and Treatment
Online Access:http://dx.doi.org/10.1155/2013/362961
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