A pH‐Sensitive Nanosized Covalent–Organic Polymer for Enhanced Tumor Photodynamic Immunotherapy by Hypoxia Relief and STAT3 Inhibition

A pH‐Sensitive Nanosized Covalent–Organic Polymer for Enhanced Tumor Photodynamic Immunotherapy by Hypoxia Relief and STAT3 Inhibition

Abstract Photodynamic therapy (PDT) is a promising cancer therapy modality by generating reactive oxygen species (ROS) and triggering immunogenic cell death. However, the therapeutic effect of PDT is strongly limited by tumor hypoxia and immunosuppressive landscape. Herein, a pH‐sensitive nanosized...

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Bibliographic Details
Main Authors: Lei Lei, Wenbin Dai, Jinchao Zhao, Angfeng Jiang, Haisheng Peng, Qiao Jin, Xiaojing Li, Zhe Tang
Format: Article
Language:English
Published: Wiley 2025-08-01
Series:Advanced Science
Subjects:
covalent–organic polymer
hypoxia relief
immunotherapy
nanomedicine
photodynamic therapy
Online Access:https://doi.org/10.1002/advs.202504860
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https://doi.org/10.1002/advs.202504860

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