Thiacetazone, an antitubercular drug that inhibits cyclopropanation of cell wall mycolic acids in mycobacteria.

Thiacetazone, an antitubercular drug that inhibits cyclopropanation of cell wall mycolic acids in mycobacteria.

<h4>Background</h4>Mycolic acids are a complex mixture of branched, long-chain fatty acids, representing key components of the highly hydrophobic mycobacterial cell wall. Pathogenic mycobacteria carry mycolic acid sub-types that contain cyclopropane rings. Double bonds at specific sites...

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Bibliographic Details
Main Authors: Anuradha Alahari, Xavier Trivelli, Yann Guérardel, Lynn G Dover, Gurdyal S Besra, James C Sacchettini, Robert C Reynolds, Geoffrey D Coxon, Laurent Kremer
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2007-12-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0001343&type=printable
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https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0001343&type=printable

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